Act Up-Paris demands post marketing approval studies : / // - prospective research of side effects on long term / - studies in "real life" conditions / - specific studies on women, children, drug users / and coinfected peoples., en bas
Headaches, fever, chills, muscle soreness, fatigue, anemia, nausea, and fingernail discolora- / tion. AZT has been associated with bone marrow suppression : anemia and/or neutropenia, particu- / larly in people with advanced HIV. Potential for severe anemia requiring blood transfusion or hospitali- / zation when used with hydroxyurea. Prolonged use of AZT has been associated with symptomatic / myopathy (muscle damage). Rare but potentially fatal toxicity with all NRTIs : pancreatitis (signs inclu- / de nausea, vomiting and abdominal pain that often spreads to the / chest and back); lactic acidosis (seen mostly in women, especially obese women; greater risk for / people with underlying liver disease; signs include deep muscle fatigue especially in legs, and diffi- / cult breathing)and enlarged fatty liver (called hepatomegaly with steatosis; check for tenderness / below ribs on right side ). Insomnia, malaise (overall ill feeling, as with the / blashs, fatigue or a flu), nasal symptoms, cough and peripheral neuropathy. in children, may cause pan- / creatitis, a potentially fatal condition. Children should be monitored carefully for this condition. / Symptoms include nausea, vomiting, clammy skin, and stomach pain that often extends to the back, / among with increased amylase in the blood. Hypersensitivity / (allergic reaction) can be fatal. People / experiencing hypersensitivity must stop / taking Ziagen and cannot take it again (cal- / led rechallenging), because of life- / threatening, and in at least three cases, fatal reaction. Hypersensitivity usually occurs within six weeks / of starting therapy, gets progressively worse and resolves quickly after permanent discontinuation. / Approximately 5 % of people taking Ziagen experienced hypersensitivity during clinical trials. The pri- / mary symptom is low-grade fever with multi-organ symptoms : muscle ache, nausea, vomiting or other / gastrointestinal upset (including abdominal pain), malaise (run-down feeling, as with the blashs, fatigue / or a flu), respiratory symptoms (cough, difficult breathing and sore throat) and possibly mils rash. / Hypersensitivity might be confused with flu during flu / season. The manufacturer recommends that people with symptoms of acute respiratory disease / consider hypersensitivity even if other diagnosis as pneumonia, bronchitis or flu is possible. If / hypersensitivity is suspected, stop therapy and contact your doctor immediately. There should be no / problem if you miss your doses for a few days and did not have an allergic reaction. Black / box warning strengthened last year when hypersensitivity was not recognized and people went back / on Ziagen, becoming seriously ill. (répétée deux fois :)